The First Folio – the first complete works of Shakespeare was published in 1623, and 2023 will mark the 400th anniversary of that publication; but is Shakespeare still relevant? My lecture discusses this issue. The English language was greatly enriched by Shakespeare: he invented 1,700 words, but what are his other legacies? In my lecture, I discuss how Hamlet and Yorick's skull has permeated popular culture. How Othello helped put Obama in the White House. Why there are starlings in the USA. How Shakespeare is the father of the Knock, Knock joke. And much, much more!